Abdominal Wall Transplantation: Indications and Outcomes

Calum Honeyman, Roisin Dolan, Helen Stark, Charles Anton Fries, Srikanth Reddy, Philip Allan, Giorgios Vrakas, Anil Vaidya, G. Dijkstra, Sijbrand H. Hofker, Tallechien Tempelman, Paul M. N. Werker, Detlev Erdmann, Kadiyala Ravindra, Debra Sudan, Peter J. Friend, Henk Giele*

*Bijbehorende auteur voor dit werk

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Abstract
Purpose of Review This article aims to review published outcomes associated with full-thickness vascularized abdominal wall
transplantation, with particular emphasis on advances in the field in the last 3 years.
Recent Findings Forty-six full-thickness vascularized abdominal wall transplants have been performed in 44 patients worldwide.
Approximately 35% of abdominal wall transplant recipients will experience at least one episode of acute rejection in the first year
after transplant, compared with rejection rates of 87.8% and 72.7% for hand and face transplant respectively. Recent evidence
suggests that combining a skin containing abdominal wall transplant with an intestinal transplant does not appear to increase
sensitization or de novo donor-specific antibody formation.
Summary Published data suggests that abdominal wall transplantation is an effective safe solution to achieve primary closure of
the abdomen after intestinal or multivisceral transplant. However, better data is needed to confirm observations made and to
determine long-term outcomes, requiring standardized data collection and reporting and collaboration between the small number
of active transplant centres around the world
Originele taal-2English
Pagina's (van-tot)279-290
Aantal pagina's12
TijdschriftCurrent Transplantation Reports
Volume7
DOI's
StatusPublished - dec-2020

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