Samenvatting
Background: Findings from both epidemiological and basic research point to the possibility that NSAIDS impede the deterioration in schizophrenia.
Methods: To study the efficacy of acetylsalicylic acid we will perform a randomized placebo controlled double- blind add- on trial of 80 inpatients and outpatients with schizophrenia, schizophreniform or schizoaffective disorder. Patients will be 1: 1 randomized to either 3 months 1000 mg acetylsalicylic acid per day or 3 months placebo, in addition to their regular antipsychotic treatment. All patients will receive pantoprazole treatment for gastroprotection. The outcomes of this study are 3- month change in psychotic and negative symptom severity, cognitive function, and several immunological parameters.
This trial may ( 1) yield a new ( adjuvant) therapy for schizophrenia and ( 2) add to the knowledge on the pathogenesis of this major psychiatric disorder.
Originele taal-2 | English |
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Artikelnummer | 31 |
Pagina's (van-tot) | Art. No. 31- |
Aantal pagina's | 6 |
Tijdschrift | Trials |
Volume | 7 |
DOI's | |
Status | Published - 23-okt.-2006 |