Acoustic Droplet Ejection Enabled Automated Reaction Scouting

Yuanze Wang, Shabnam Shaabani, Maryam Ahmadianmoghaddam, Li Gao, Ruixue Xu, Katarzyna Kurpiewska, Justyna Kalinowska-Tluscik, Joe Olechno, Richard Ellson, Michael Kossenjans, Victoria Helan, Matthew Groves, Alexander Dömling

OnderzoeksoutputAcademicpeer review

27 Citaten (Scopus)
304 Downloads (Pure)

Samenvatting

Miniaturization and acceleration of synthetic chemistry are critically important for rapid property optimization in pharmaceutical, agrochemical, and materials research and development. However, in most laboratories organic synthesis is still performed on a slow, sequential, and material-consuming scale and not validated for multiple substrate combinations. Herein, we introduce fast and touchless acoustic droplet ejection (ADE) technology into small-molecule chemistry to transfer building blocks by nL droplets and to scout a newly designed isoquinoline synthesis. With each compound in a discrete well, 384 random derivatives were synthesized in an automated fashion, and their quality was monitored by SFC-MS and TLC-UV-MS analysis. We exemplify a pipeline of fast and efficient nmol scouting to mmol- and mol-scale synthesis for the discovery of a useful novel reaction with great scope.

Originele taal-2English
Pagina's (van-tot)451-457
Aantal pagina's7
TijdschriftACS central science
Volume5
Nummer van het tijdschrift3
DOI's
StatusPublished - 27-mrt-2019

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