Acquired bleeding disorders

Andreas Tiede*, Barbara Zieger, Ton Lisman

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

25 Downloads (Pure)

Samenvatting

Acquired bleeding disorders can accompany hematological, neoplastic, autoimmune, cardiovascular or liver diseases, but can sometimes also arise spontaneously. They can manifest as single factor deficiencies or as complex hemostatic abnormalities. This review addresses (a) acquired hemophilia A, an autoimmune disorder characterized by inhibitory autoantibodies against coagulation factor VIII; (b) acquired von Willebrand syndrome in patients with cardiovascular disorders, where shear stress abnormalities result in destruction of von Willebrand factor; and (c) liver function disorders that comprise complex changes in pro- and anti-hemostatic factors, whose clinical implications are often difficult to predict. The article provides an overview on the pathophysiology, diagnostic tests and state-of-the-art treatment strategies.

Originele taal-2English
Pagina's (van-tot)5-13
Aantal pagina's9
TijdschriftHaemophilia
Volume27
Nummer van het tijdschriftS3
Vroegere onlinedatum1-jun-2020
DOI's
StatusPublished - feb-2021

Citeer dit