Advanced Modeling of Peripheral Neuro-Effector Communication and -Plasticity

Pien A Goldsteen, Amalia M Dolga, Reinoud Gosens*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articlepeer review

1 Citaat (Scopus)

Samenvatting

The peripheral nervous system (PNS) plays crucial roles in physiology and disease. Neuro-effector communication and neuroplasticity of the PNS are poorly studied, since suitable models are lacking. The emergence of human pluripotent stem cells (hPSCs) has great promise to resolve this deficit. hPSC-derived PNS neurons, integrated into organ-on-a-chip systems or organoid cultures, allow co-cultures with cells of the local microenvironment to study neuro-effector interactions and to probe mechanisms underlying neuroplasticity.

Originele taal-2English
Pagina's (van-tot)348-357
Aantal pagina's10
TijdschriftPhysiology
Volume35
Nummer van het tijdschrift5
DOI's
StatusPublished - sep-2020

Citeer dit