TY - JOUR
T1 - Advances in fluorescent carbon dots for biomedical applications
AU - Koutsogiannis, Panagiotis
AU - Thomou, Eleni
AU - Stamatis, Haralambos
AU - Gournis, Dimitrios
AU - Rudolf, Petra
N1 - Funding Information:
P.K. acknowledges the TopMaster Nanoscience scholarship from the Zernike Institute for Advanced Materials under the Bonus Incentive Scheme (BIS) of the Netherlands’ Ministry of Education, Science, and Culture. E.T. thanks the Hellenic Foundation for Research and Innovation (HFRI) and the General Secretariat for Research and Technology (GSRT) for the HFRI PhD Fellowship grant [GA. no. 1829] and the PhD Scholarship programme of the University of Groningen for funding her graduate work.
Publisher Copyright:
© 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2020/5/13
Y1 - 2020/5/13
N2 - Carbon Dots are an emerging class of carbon-based nanoparticles, which since their discovery have attracted tremendous attention because of their exceptional fluorescent, chemical and mechanical properties as well as high photostability and biocompatibility. This unique combination of outstanding characteristics, together with the ease with which they can be synthesized, qualify carbon dots as highly promising materials for applications in electronics and biology, in particular, for biosensing, bioimaging, biotherapy and drug delivery. In this review, we present some of the most recent applications of carbon dots in biology and medicine, concentrating on their fluorescence properties, biocompatibility and efficiency; we also discuss how improvements could prompt their use in human studies. We illustrate how carbon dots, prepared through several facile and cost-effective methods by either the bottom-up or the top-down route, can be used for imaging cells and bacteria and as sensing probes of metal cations. Moreover, we explain how their astonishing versatility has given rise to new biotherapy methods especially in the field of cancer theranostics.
AB - Carbon Dots are an emerging class of carbon-based nanoparticles, which since their discovery have attracted tremendous attention because of their exceptional fluorescent, chemical and mechanical properties as well as high photostability and biocompatibility. This unique combination of outstanding characteristics, together with the ease with which they can be synthesized, qualify carbon dots as highly promising materials for applications in electronics and biology, in particular, for biosensing, bioimaging, biotherapy and drug delivery. In this review, we present some of the most recent applications of carbon dots in biology and medicine, concentrating on their fluorescence properties, biocompatibility and efficiency; we also discuss how improvements could prompt their use in human studies. We illustrate how carbon dots, prepared through several facile and cost-effective methods by either the bottom-up or the top-down route, can be used for imaging cells and bacteria and as sensing probes of metal cations. Moreover, we explain how their astonishing versatility has given rise to new biotherapy methods especially in the field of cancer theranostics.
KW - 33.50.Dq Fluorescence and phosphorescence spectra
KW - 42.40.My applications
KW - 42.62.Be Biological and medical applications
KW - 73.21.La Quantum dots
KW - bioimaging
KW - biosensing
KW - biotherapy
KW - Carbon dots
UR - http://www.scopus.com/inward/record.url?scp=85084729141&partnerID=8YFLogxK
U2 - 10.1080/23746149.2020.1758592
DO - 10.1080/23746149.2020.1758592
M3 - Review article
SN - 2374-6149
VL - 5
JO - Advances in nuclear physics
JF - Advances in nuclear physics
IS - 1
M1 - 1758592
ER -