Advances of epigenetic editing

Rutger A F Gjaltema, Marianne G Rots*

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

21 Citaten (Scopus)
184 Downloads (Pure)

Samenvatting

Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. ,CRISPR/dCas9 Here, were review the current applications of these epigenetic editing tools in mammalians and shed light on biochemical improvements that facilitate versatile applications.

Originele taal-2English
Pagina's (van-tot)75-81
Aantal pagina's7
TijdschriftCurrent Opinion in Chemical Biology
Volume57
Vroegere onlinedatum29-jun.-2020
DOI's
StatusPublished - aug.-2020

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