Advances of epigenetic editing

Rutger A F Gjaltema; Marianne G Rots

doi:10.1016/j.cbpa.2020.04.020

Advances of epigenetic editing

Rutger A F Gjaltema, Marianne G Rots^*

^*Bijbehorende auteur voor dit werk

Onderzoeksoutput › peer review

21 Citaten (Scopus)

184 Downloads (Pure)

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Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. ,CRISPR/dCas9 Here, were review the current applications of these epigenetic editing tools in mammalians and shed light on biochemical improvements that facilitate versatile applications.

Originele taal-2	English
Pagina's (van-tot)	75-81
Aantal pagina's	7
Tijdschrift	Current Opinion in Chemical Biology
Volume	57
Vroegere onlinedatum	29-jun.-2020
DOI's	https://doi.org/10.1016/j.cbpa.2020.04.020
Status	Published - aug.-2020

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10.1016/j.cbpa.2020.04.020Licentie: CC BY

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title = "Advances of epigenetic editing",

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T1 - Advances of epigenetic editing

AU - Gjaltema, Rutger A F

AU - Rots, Marianne G

PY - 2020/8

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N2 - Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. ,CRISPR/dCas9 Here, were review the current applications of these epigenetic editing tools in mammalians and shed light on biochemical improvements that facilitate versatile applications.

AB - Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. ,CRISPR/dCas9 Here, were review the current applications of these epigenetic editing tools in mammalians and shed light on biochemical improvements that facilitate versatile applications.

U2 - 10.1016/j.cbpa.2020.04.020

DO - 10.1016/j.cbpa.2020.04.020

M3 - Review article

C2 - 32619853

VL - 57

SP - 75

EP - 81

JO - Current Opinion in Chemical Biology

JF - Current Opinion in Chemical Biology

SN - 1367-5931

ER -