Aging of murine hematopoietic stem cells

Edyta Wόjtowicz, Gerald De Haan, Evgenia Verovskaya*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

Samenvatting

Hematopoietic stem cells (HSCs) are unique in their ability to self-renew and differentiate into all mature blood lineages. The equilibrium between these processes is crucial for tissue maintenance during the lifetime of the organism. However, with age the functionality of HSCs declines, resulting indevelopment of anemias, deficiencies of immune response, and increased risk of hematopoietic malignancies. Aged HSCs are characterized by preferential differentiation toward myeloid lineage, impaired self-renewal, and engraftment. Recent evidence provides clues to the understanding of these processeson cellular and molecular levels. Key components contributing to stem cell aging are shifts in the transcriptome and epigenome, accompanied by dysfunction of DNA repair pathways. In this chapter we will focus on studies and conceptual models of murine HSC aging.

Originele taal-2English
TitelStem Cell Aging
SubtitelMechanisms, Consequences, Rejuvenation
UitgeverijSpringer-Verlag Vienna
Pagina's107-126
Aantal pagina's20
ISBN van elektronische versie9783709112328
ISBN van geprinte versie9783709112311
DOI's
StatusPublished - 1-jan-2015

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