Allergen-specific subcutaneous immunotherapy in allergic asthma: immunologic mechanisms and improvement

Yousef A. Taher*, Paul A. J. Henricks, Antoon J. M. van Oosterhout

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

11 Citaten (Scopus)
205 Downloads (Pure)

Samenvatting

Allergic asthma is a disease characterized by persistent allergen-driven airway inflammation, remodeling, and airway hyperresponsiveness. CD4(+) T-cells, especially T-helper type 2 cells, play a critical role in orchestrating the disease process through the release of the cytokines IL-4, IL-5, and IL-13. Allergen-specific immunotherapy (SIT) is currently the only treatment with a long-term effect via modifying the natural course of allergy by interfering with the underlying immunological mechanisms. However, although SIT is effective in allergic rhinitis and insect venom allergy, in allergic asthma it seldom results in complete alleviation of the symptoms. Improvement of SIT is needed to enhance its efficacy in asthmatic patients. Herein, the immunoregulatory mechanisms underlying the beneficial effects of SIT are discussed with the ultimate aim to improve its treatment efficacy.

Originele taal-2English
Artikelnummer5303
Aantal pagina's11
TijdschriftLibyan journal of medicine
Volume5
DOI's
StatusPublished - 2010

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