Aminomutases: Mechanistic diversity, biotechnological applications and future perspectives

Bian Wu, Wiktor Szymanski, Matthew M. Heberling, Ben L. Feringa, Dick B. Janssen*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

37 Citaten (Scopus)

Samenvatting

Aminomutases carry out the chemically challenging exchange of a hydrogen atom and an amine substituent present on neighboring carbon atoms. In recent years, aminomutases have been intensively investigated for their biophysical, structural and mechanistic characteristics. The reactions catalyzed by these enzymes have considerable potential for biotechnological applications. Here, we present an overview of this diverse group of enzymes, with a focus on enzymatic mechanisms and recent developments in their use in applied biocatalysis.

Originele taal-2English
Pagina's (van-tot)352-362
Aantal pagina's11
TijdschriftTrends in Biotechnology
Volume29
Nummer van het tijdschrift7
DOI's
StatusPublished - 2011

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