Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction

Pravin Patil, Katarzyna Kurpiewska, Justyna Kalinowska-Tłuścik, Alexander Dömling

OnderzoeksoutputAcademicpeer review

15 Citaten (Scopus)
281 Downloads (Pure)


Ammonia in the tetrazole Ugi variation together with α-amino acid methyl ester-derived isocyanides provides tetrazolopiperidinones in good to high yields in one pot. The scope and limitations of this reaction were investigated by performing >70 reactions. The scaffold is useful to fill high-throughput screening decks and in structure-based drug design.
Originele taal-2English
Pagina's (van-tot)343-350
Aantal pagina's8
TijdschriftAcs combinatorial science
Nummer van het tijdschrift5
StatusPublished - 8-mei-2017

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