Amplification and protein overexpression of cyclin D1: Predictor of occult nodal metastasis in early oral cancer

Rob Noorlag; Koos Boeve; Max J. H. Witjes; Ronald Koole; Ton L. M. Peeters; Ed Schuuring; Stefan M. Willems; Robert J. J. van Es

doi:10.1002/hed.24584

Amplification and protein overexpression of cyclin D1: Predictor of occult nodal metastasis in early oral cancer

Rob Noorlag, Koos Boeve, Max J. H. Witjes, Ronald Koole, Ton L. M. Peeters, Ed Schuuring, Stefan M. Willems, Robert J. J. van Es^*

^*Corresponding author voor dit werk

Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE)

Onderzoeksoutput: Article › Academic › peer review

24 Citaten (Scopus)

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Background. Accurate nodal staging is pivotal for treatment planning in early (stage I-II) oral cancer. Unfortunately, current imaging modalities lack sensitivity to detect occult nodal metastases. Chromosomal region 11q13, including genes CCND1, Fas-associated death domain (FADD), and CTTN, is often amplified in oral cancer with nodal metastases. However, evidence in predicting occult nodal metastases is limited.

Methods. In 158 patients with early tongue and floor of mouth (FOM) squamous cell carcinomas, both CCND1 amplification and cyclin D1, FADD, and cortactin protein expression were correlated with occult nodal metastases.

Results. CCND1 amplification and cyclin D1 expression correlated with occult nodal metastases. Cyclin D1 expression was validated in an independent multicenter cohort, confirming the correlation with occult nodal metastases in early FOM cancers.

Conclusion. Cyclin D1 is a predictive biomarker for occult nodal metastases in early FOM cancers. Prospective research on biopsy material should confirm these results before implementing its use in routine clinical practice. (C) 2016 Wiley Periodicals, Inc.

Originele taal-2	English
Pagina's (van-tot)	326-333
Aantal pagina's	8
Tijdschrift	Head and Neck: Journal of the Sciences and Specialties of the Head and Neck
Volume	39
Nummer van het tijdschrift	2
DOI's	https://doi.org/10.1002/hed.24584
Status	Published - feb.-2017
Evenement	Spring Congress of the Dutch-Society-of-Oral-and-Maxillofacial-Surgery (NVMKA) - Rotterdam, Netherlands Duur: 29-mei-2015 → …

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Noorlag, R., Boeve, K., Witjes, M. J. H., Koole, R., Peeters, T. L. M., Schuuring, E., Willems, S. M., & van Es, R. J. J. (2017). Amplification and protein overexpression of cyclin D1: Predictor of occult nodal metastasis in early oral cancer. Head and Neck: Journal of the Sciences and Specialties of the Head and Neck, 39(2), 326-333. https://doi.org/10.1002/hed.24584

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title = "Amplification and protein overexpression of cyclin D1: Predictor of occult nodal metastasis in early oral cancer",

abstract = "Background. Accurate nodal staging is pivotal for treatment planning in early (stage I-II) oral cancer. Unfortunately, current imaging modalities lack sensitivity to detect occult nodal metastases. Chromosomal region 11q13, including genes CCND1, Fas-associated death domain (FADD), and CTTN, is often amplified in oral cancer with nodal metastases. However, evidence in predicting occult nodal metastases is limited.Methods. In 158 patients with early tongue and floor of mouth (FOM) squamous cell carcinomas, both CCND1 amplification and cyclin D1, FADD, and cortactin protein expression were correlated with occult nodal metastases.Results. CCND1 amplification and cyclin D1 expression correlated with occult nodal metastases. Cyclin D1 expression was validated in an independent multicenter cohort, confirming the correlation with occult nodal metastases in early FOM cancers.Conclusion. Cyclin D1 is a predictive biomarker for occult nodal metastases in early FOM cancers. Prospective research on biopsy material should confirm these results before implementing its use in routine clinical practice. (C) 2016 Wiley Periodicals, Inc.",

keywords = "CCND1, cyclin D1, early oral cancer, occult nodal metastasis, biomarker, SQUAMOUS-CELL CARCINOMA, MESSENGER-RNA LEVELS, NECK DISSECTION, MULTICENTER TRIAL, COPY NUMBER, EXPRESSION, BIOPSY, HEAD, GENE, MANAGEMENT",

author = "Rob Noorlag and Koos Boeve and Witjes, {Max J. H.} and Ronald Koole and Peeters, {Ton L. M.} and Ed Schuuring and Willems, {Stefan M.} and {van Es}, {Robert J. J.}",

note = "{\textcopyright} 2016 Wiley Periodicals, Inc.; Spring Congress of the Dutch-Society-of-Oral-and-Maxillofacial-Surgery (NVMKA) ; Conference date: 29-05-2015",

year = "2017",

month = feb,

doi = "10.1002/hed.24584",

language = "English",

volume = "39",

pages = "326--333",

journal = "Head and Neck: Journal of the Sciences and Specialties of the Head and Neck",

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T1 - Amplification and protein overexpression of cyclin D1

T2 - Spring Congress of the Dutch-Society-of-Oral-and-Maxillofacial-Surgery (NVMKA)

AU - Noorlag, Rob

AU - Boeve, Koos

AU - Witjes, Max J. H.

AU - Koole, Ronald

AU - Peeters, Ton L. M.

AU - Schuuring, Ed

AU - Willems, Stefan M.

AU - van Es, Robert J. J.

PY - 2017/2

Y1 - 2017/2

N2 - Background. Accurate nodal staging is pivotal for treatment planning in early (stage I-II) oral cancer. Unfortunately, current imaging modalities lack sensitivity to detect occult nodal metastases. Chromosomal region 11q13, including genes CCND1, Fas-associated death domain (FADD), and CTTN, is often amplified in oral cancer with nodal metastases. However, evidence in predicting occult nodal metastases is limited.Methods. In 158 patients with early tongue and floor of mouth (FOM) squamous cell carcinomas, both CCND1 amplification and cyclin D1, FADD, and cortactin protein expression were correlated with occult nodal metastases.Results. CCND1 amplification and cyclin D1 expression correlated with occult nodal metastases. Cyclin D1 expression was validated in an independent multicenter cohort, confirming the correlation with occult nodal metastases in early FOM cancers.Conclusion. Cyclin D1 is a predictive biomarker for occult nodal metastases in early FOM cancers. Prospective research on biopsy material should confirm these results before implementing its use in routine clinical practice. (C) 2016 Wiley Periodicals, Inc.

AB - Background. Accurate nodal staging is pivotal for treatment planning in early (stage I-II) oral cancer. Unfortunately, current imaging modalities lack sensitivity to detect occult nodal metastases. Chromosomal region 11q13, including genes CCND1, Fas-associated death domain (FADD), and CTTN, is often amplified in oral cancer with nodal metastases. However, evidence in predicting occult nodal metastases is limited.Methods. In 158 patients with early tongue and floor of mouth (FOM) squamous cell carcinomas, both CCND1 amplification and cyclin D1, FADD, and cortactin protein expression were correlated with occult nodal metastases.Results. CCND1 amplification and cyclin D1 expression correlated with occult nodal metastases. Cyclin D1 expression was validated in an independent multicenter cohort, confirming the correlation with occult nodal metastases in early FOM cancers.Conclusion. Cyclin D1 is a predictive biomarker for occult nodal metastases in early FOM cancers. Prospective research on biopsy material should confirm these results before implementing its use in routine clinical practice. (C) 2016 Wiley Periodicals, Inc.

KW - CCND1

KW - cyclin D1

KW - early oral cancer

KW - occult nodal metastasis

KW - biomarker

KW - SQUAMOUS-CELL CARCINOMA

KW - MESSENGER-RNA LEVELS

KW - NECK DISSECTION

KW - MULTICENTER TRIAL

KW - COPY NUMBER

KW - EXPRESSION

KW - BIOPSY

KW - HEAD

KW - GENE

KW - MANAGEMENT

U2 - 10.1002/hed.24584

DO - 10.1002/hed.24584

M3 - Article

C2 - 27653309

SN - 1043-3074

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SP - 326

EP - 333

JO - Head and Neck: Journal of the Sciences and Specialties of the Head and Neck

JF - Head and Neck: Journal of the Sciences and Specialties of the Head and Neck

IS - 2

Y2 - 29 May 2015

ER -

Amplification and protein overexpression of cyclin D1: Predictor of occult nodal metastasis in early oral cancer

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