An assessment of the correlation between robust CT-derived ventilation and pulmonary function test in a cohort with no respiratory symptoms

Girish B. Nair, Craig J. Galban, Sayf Al-Katib, Robert Podolsky, Maarten van den Berge, Craig Stevens, Edward Castillo*

*Bijbehorende auteur voor dit werk

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Objective: To evaluate CT-ventilation imaging (CTVI) within a well-characterized, healthy cohort with no respiratory symptoms and examine the correlation between CTVI and concurrent pulmonary function test (PFT).

Methods: CT scans and PFTs from 77 Caucasian participants in the NORM dataset (clinicaltrials.gov NCT00848406) were analyzed. CTVI was generated using the robust Integrated Jacobian Formulation (IJF) method, IJF estimated total lung capacity (TLC) was computed from CTVI. Bias-adjusted Pearson's correlation between PFT and IJF-based TLC was computed.

Results: IJF- and PFT-measured TLC showed a good correlation for both males and females [males: 0.657, 95%CI (0.438-0.797): females: 0.667, 95%CI (0.416-0.817)] When adjusting for age, height, smoking, and abnormal CT scan, correlation moderated [males: 0.432, 95%CI (0.129-0.655); females: 0.540, 95%CI (0.207-0.753)] Visual inspection of CTVI revealed participants who had functional defects, despite the fact that all participant had normal high-resolution CT scan.

Conclusion: In this study, we demonstrate that IJF computed CT VI has good correlation with concurrent PFT in a well-validated patient cohort with no respiratory symptoms.

Advances in knowledge: IJF-computed CTVI's overall numerical robustness and consistency with PFT support its potential as a method for providing spatiotemporal assessment of high and low function areas on volumetric non-contrast CT scan.

Originele taal-2English
Artikelnummer20201218
Aantal pagina's4
TijdschriftBritish journal of radiology
Volume94
Nummer van het tijdschrift1118
Vroegere onlinedatum15-dec-2020
DOI's
StatusPublished - 2021

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