An assessment of the correlation between robust CT-derived ventilation and pulmonary function test in a cohort with no respiratory symptoms

Girish B. Nair, Craig J. Galban, Sayf Al-Katib, Robert Podolsky, Maarten van den Berge, Craig Stevens, Edward Castillo*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

11 Downloads (Pure)


Objective: To evaluate CT-ventilation imaging (CTVI) within a well-characterized, healthy cohort with no respiratory symptoms and examine the correlation between CTVI and concurrent pulmonary function test (PFT).

Methods: CT scans and PFTs from 77 Caucasian participants in the NORM dataset ( NCT00848406) were analyzed. CTVI was generated using the robust Integrated Jacobian Formulation (IJF) method, IJF estimated total lung capacity (TLC) was computed from CTVI. Bias-adjusted Pearson's correlation between PFT and IJF-based TLC was computed.

Results: IJF- and PFT-measured TLC showed a good correlation for both males and females [males: 0.657, 95%CI (0.438-0.797): females: 0.667, 95%CI (0.416-0.817)] When adjusting for age, height, smoking, and abnormal CT scan, correlation moderated [males: 0.432, 95%CI (0.129-0.655); females: 0.540, 95%CI (0.207-0.753)] Visual inspection of CTVI revealed participants who had functional defects, despite the fact that all participant had normal high-resolution CT scan.

Conclusion: In this study, we demonstrate that IJF computed CT VI has good correlation with concurrent PFT in a well-validated patient cohort with no respiratory symptoms.

Advances in knowledge: IJF-computed CTVI's overall numerical robustness and consistency with PFT support its potential as a method for providing spatiotemporal assessment of high and low function areas on volumetric non-contrast CT scan.

Originele taal-2English
Aantal pagina's4
TijdschriftBritish journal of radiology
Nummer van het tijdschrift1118
Vroegere onlinedatum15-dec-2020
StatusPublished - 2021

Citeer dit