An atom efficient synthesis of tamoxifen

Dorus Heijnen, Milan van Zuijlen, Filippo Tosi, Ben L. Feringa*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

7 Citaten (Scopus)
68 Downloads (Pure)

Samenvatting

The direct carbolithiation of diphenylacetylenes and their cross-coupling procedure taking advantage of the intermediate alkenyllithium reagents are presented. By employing our recently discovered highly active palladium nanoparticle based catalyst, we were able to couple an alkenyllithium reagent with a high (Z/E) selectivity (10 : 1) and good yield to give the breast cancer drug tamoxifen in just 2 steps from commercially available starting materials and with excellent atom economy and reaction mass efficiency.

Originele taal-2English
Pagina's (van-tot)2315-2320
Aantal pagina's6
TijdschriftOrganic & Biomolecular Chemistry
Volume17
Nummer van het tijdschrift9
DOI's
StatusPublished - 7-mrt-2019

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