An emerging role for microglia in stress-effects on memory

Jeniffer Sanguino-Gomez*, Jacobus C. Buurstede, Oihane Abiega, Carlos P. Fitzsimons, Paul J. Lucassen, Bart J. L. Eggen, Sylvie L. Lesuis, Onno C. Meijer, Harm J. Krugers

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articlepeer review

13 Citaten (Scopus)
84 Downloads (Pure)


Stressful experiences evoke, among others, a rapid increase in brain (nor)epinephrine (NE) levels and a slower increase in glucocorticoid hormones (GCs) in the brain. Microglia are key regulators of neuronal function and contain receptors for NE and GCs. These brain cells may therefore potentially be involved in modulating stress effects on neuronal function and learning and memory. In this review, we discuss that stress induces (1) an increase in microglial numbers as well as (2) a shift toward a pro-inflammatory profile. These microglia have (3) impaired crosstalk with neurons and (4) disrupted glutamate signaling. Moreover, microglial immune responses after stress (5) alter the kynurenine pathway through metabolites that impair glutamatergic transmission. All these effects could be involved in the impairments in memory and in synaptic plasticity caused by (prolonged) stress, implicating microglia as a potential novel target in stress-related memory impairments.

Originele taal-2English
Pagina's (van-tot)2491-2518
Aantal pagina's28
TijdschriftEuropean Journal of Neuroscience
Nummer van het tijdschrift9-10
Vroegere onlinedatum16-mrt.-2021
StatusPublished - mei-2022

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