An oncological view on the blood-testis barrier

J Bart, HJM Groen, WTA van der Graaf, H Hollema, NH Hendrikse, W Vaalburg, DT Sleijfer, EGE de Vries*

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

127 Citaten (Scopus)

Samenvatting

The function of the blood-testis barrier is to protect germ cells from harmful influences; thus, it also impedes the delivery of chemotherapeutic drugs to the testis. The barrier has three components: first, a physicochemical barrier consisting of continuous capillaries, Sertoli cells in the tubular wall, connected together with narrow tight junctions, and a myoid-cell layer around the seminiferous tubule. Second, an efflux-pump barrier that contains P-glycoprotein in the luminal capillary endothelium and on the myoid-cell layer; and multidrug-resistance associated protein 1 located basolaterally on Sertoli cells. Third, an immunological barrier, consisting of Fas ligand on Sertoli cells. Inhibition of P-glycoprotein function offers the opportunity to increase the delivery of cytotoxic drugs to the testis. In the future, visualisation of function in the blood-testis barrier may also be helpful to identify groups of patients in whom testis conservation is safe or to select drugs that are less harmful to fertility.

Originele taal-2English
Pagina's (van-tot)357-363
Aantal pagina's7
TijdschriftLancet Oncology
Volume3
Nummer van het tijdschrift6
StatusPublished - jun-2002

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