@article{beba86703e7d413bbc5c7c46f6fad180,
title = "Analysis of biopharmaceutical proteins in biological matrices by LC-MS/MS I. Sample preparation",
abstract = "Part I of this review discusses sample-preparation aspects of quantifying biopharmaceutical proteins in complex biological matrices by LC-MS/MS with a focus on blood-derived body fluids. We conclude Part I with a short overview over options for automating the entire analytical procedure, which is indispensable for routine applications in pharmacokinetic and clinical studies. (C) 2013 Elsevier Ltd. All rights reserved.",
keywords = "Analytical procedure, Automation, Biological matrix, Biopharmaceuticals, Blood-derived body fluid, Clinical study, Liquid chromatography with tandem mass spectrometry (LC-MS/MS), Pharmacokinetic study, Protein, Sample preparation, TANDEM MASS-SPECTROMETRY, PERFORMANCE LIQUID-CHROMATOGRAPHY, PEPTIDE IMMUNOAFFINITY ENRICHMENT, ABSOLUTE QUANTIFICATION, MONOCLONAL-ANTIBODY, INTERNAL STANDARD, HUMAN SERUM, THERAPEUTIC PROTEINS, TRYPSIN DIGESTION, DEAMIDATION",
author = "Rainer Bischoff and Bronsema, {Kees J.} and {van de Merbel}, {Nico C.}",
year = "2013",
doi = "10.1016/j.trac.2012.11.015",
language = "English",
volume = "48",
pages = "41--51",
journal = "TrAC-Trends in Analytical Chemistry",
issn = "0165-9936",
publisher = "ELSEVIER SCI LTD",
}