Anterior segment optical coherence tomography angiography: Development and application of OCT angiography for corneal vascularisation

Marcus Ang Han Nian

Anterior segment optical coherence tomography angiography: Development and application of OCT angiography for corneal vascularisation

Marcus Ang Han Nian

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Hoornvliesziekten behoren tot de meest voorkomende oorzaken van blindheid in de wereld. Vascularisatie van het hoornvlies is een veelvoorkomende en potentieel visusbedreigend probleem; het gezonde hoornvlies heeft geen vaten en vascularisatie is het gevolg van in principe ieder ontstekingsproces waarbij het hoornvlies is betrokken. De huidige gouden standaard voor beeldvorming van vascularisatie is invasief; het vereist injectie van een intraveneuze contrastvloeistof (indocyanine groen, ICG). OCT-angiografie (OCTA) is een nieuwe, niet-invasieve beeldvormingstechniek die is ontwikkeld om de vaten van het netvlies te kunnen afbeelden. De huidige OCTA-systemen zijn echter niet geoptimaliseerd voor het hoornvlies. De hoofddoelen van mijn proefschrift zijn (1) om te laten zien dat OCTA-systemen die zijn ontworpen voor het netvlies (achtersegment van het oog) ook gebruikt kunnen worden voor het afbeelden van het hoornvlies (voorsegment van het oog), (2) om een methode te ontwikkelen om OCTA-beelden van het hoornvlies te analyseren en kwantificeren en (3) om OCTA te vergelijken met de huidige gouden standaard, te weten ICG-angiografie (ICGA), en met histologie en confocale microscopie. Het onderzoek beschreven in dit proefschrift opent de mogelijkheid voor een nieuwe, niet invasieve en snelle beeldvormingstechniek om het hoornvlies en de hoornvliesvaten tegelijk te evalueren. De resultaten ondersteunen dat deze nieuwe techniek in staat is om snel, veilig en betrouwbaar hoornvliesvaten te evalueren, met een goede correlatie met andere klinische instrumenten die in onze praktijk worden gebruikt, en met een mogelijkheid om veranderingen in de loop van de tijd waar te nemen.

Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Toekennende instantie	Rijksuniversiteit Groningen
Begeleider(s)/adviseur	Jansonius, Nomdo, Supervisor Schmetterer, L., Supervisor, Externe Persoon Mehta, J., Supervisor, Externe Persoon
Datum van toekenning	17-apr.-2019
Plaats van publicatie	[Groningen]
Uitgever	University of Groningen
Gedrukte ISBN's	9789403415741
Elektronische ISBN's	9789403415758
Status	Published - 2019

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Title and contentsFinal publisher's version, 199 KB
Chapter 1Final publisher's version, 3,1 MB
Chapter 2Final publisher's version, 3,15 MB
Chapter 3Final publisher's version, 1,06 MB
Chapter 4Final publisher's version, 2,33 MB
Chapter 5Final publisher's version, 565 KB
Chapter 6Final publisher's version, 3,08 MB
Chapter 7Final publisher's version, 1,46 MB
Chapter 8Final publisher's version, 627 KB
Appendix 1Final publisher's version, 15 MB
SummaryFinal publisher's version, 60,9 KB
SamenvattingFinal publisher's version, 61,5 KB
AcknowledgementFinal publisher's version, 67,1 KB
List of publications Final publisher's version, 120 KB
Complete thesisFinal publisher's version, 30,4 MB
PropositionsFinal publisher's version, 44,2 KB

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@phdthesis{69f3289db53d4c16a392234804f4c843,

title = "Anterior segment optical coherence tomography angiography: Development and application of OCT angiography for corneal vascularisation",

abstract = "Corneal diseases are among the most common causes of blindness in the world. Vascularization of the cornea is a common and potentially vision-threatening problem; the healthy cornea has no vessels and vascularization is the result of every inflammatory process in which the cornea is involved. The current gold standard for imaging vascularization is invasive; it requires injection of an intravenous contrast fluid (indocyanine green, ICG). OCT angiography (OCTA) is a new, non-invasive imaging technique that has been developed to visualize the vessels of the retina. However, the current OCTA systems are not optimized for the cornea. The main goals of my PhD thesis are (1) to establish that OCTA systems designed for the retina (posterior segment of the eye) can also be used to image the cornea (anterior segment of the eye), (2) to to design a method to analyze and quantify OCTA images of the cornea and (3) to compare OCTA with the current gold standard, ICG angiography (ICGA), histology, and confocal microscopy. The research described in this thesis opens the possibility for a new, non-invasive and rapid imaging technique to evaluate the cornea and corneal vessels simultaneously. The results support that this new technique is capable of evaluating corneal vessels in a fast, safe, and reliable manner, with a good correlation with other clinical tools used in our practice, and with a possibility to observe changes over time. The same technique could also be used in a broader range of clinical applications in ophthalmology such as glaucoma.",

author = "{Ang Han Nian}, Marcus",

year = "2019",

language = "English",

isbn = "9789403415741",

publisher = "University of Groningen",

school = "University of Groningen",

}

TY - BOOK

T1 - Anterior segment optical coherence tomography angiography

T2 - Development and application of OCT angiography for corneal vascularisation

AU - Ang Han Nian, Marcus

PY - 2019

Y1 - 2019

N2 - Corneal diseases are among the most common causes of blindness in the world. Vascularization of the cornea is a common and potentially vision-threatening problem; the healthy cornea has no vessels and vascularization is the result of every inflammatory process in which the cornea is involved. The current gold standard for imaging vascularization is invasive; it requires injection of an intravenous contrast fluid (indocyanine green, ICG). OCT angiography (OCTA) is a new, non-invasive imaging technique that has been developed to visualize the vessels of the retina. However, the current OCTA systems are not optimized for the cornea. The main goals of my PhD thesis are (1) to establish that OCTA systems designed for the retina (posterior segment of the eye) can also be used to image the cornea (anterior segment of the eye), (2) to to design a method to analyze and quantify OCTA images of the cornea and (3) to compare OCTA with the current gold standard, ICG angiography (ICGA), histology, and confocal microscopy. The research described in this thesis opens the possibility for a new, non-invasive and rapid imaging technique to evaluate the cornea and corneal vessels simultaneously. The results support that this new technique is capable of evaluating corneal vessels in a fast, safe, and reliable manner, with a good correlation with other clinical tools used in our practice, and with a possibility to observe changes over time. The same technique could also be used in a broader range of clinical applications in ophthalmology such as glaucoma.

AB - Corneal diseases are among the most common causes of blindness in the world. Vascularization of the cornea is a common and potentially vision-threatening problem; the healthy cornea has no vessels and vascularization is the result of every inflammatory process in which the cornea is involved. The current gold standard for imaging vascularization is invasive; it requires injection of an intravenous contrast fluid (indocyanine green, ICG). OCT angiography (OCTA) is a new, non-invasive imaging technique that has been developed to visualize the vessels of the retina. However, the current OCTA systems are not optimized for the cornea. The main goals of my PhD thesis are (1) to establish that OCTA systems designed for the retina (posterior segment of the eye) can also be used to image the cornea (anterior segment of the eye), (2) to to design a method to analyze and quantify OCTA images of the cornea and (3) to compare OCTA with the current gold standard, ICG angiography (ICGA), histology, and confocal microscopy. The research described in this thesis opens the possibility for a new, non-invasive and rapid imaging technique to evaluate the cornea and corneal vessels simultaneously. The results support that this new technique is capable of evaluating corneal vessels in a fast, safe, and reliable manner, with a good correlation with other clinical tools used in our practice, and with a possibility to observe changes over time. The same technique could also be used in a broader range of clinical applications in ophthalmology such as glaucoma.

M3 - Thesis fully internal (DIV)

SN - 9789403415741

PB - University of Groningen

CY - [Groningen]

ER -

Anterior segment optical coherence tomography angiography: Development and application of OCT angiography for corneal vascularisation

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