Antibiotic resistance plasmids cointegrated into a megaplasmid harbouring the blaOXA-427 carbapenemase gene

Stefanie Desmet; Suruchi Nepal; Jan Maarten van Dijl; Marc Van Ranst; Monika A Chlebowicz; John W Rossen; Jeroen K J Van Houdt; Piet Maes; Katrien Lagrou; Erik Bathoorn

doi:10.1128/AAC.01448-17

Antibiotic resistance plasmids cointegrated into a megaplasmid harbouring the blaOXA-427 carbapenemase gene

Stefanie Desmet, Suruchi Nepal, Jan Maarten van Dijl, Marc Van Ranst, Monika A Chlebowicz, John W Rossen, Jeroen K J Van Houdt, Piet Maes, Katrien Lagrou, Erik Bathoorn

Onderzoeksoutput › Academic › peer review

19 Citaten (Scopus)

295 Downloads (Pure)

Samenvatting

OXA-427 is a new class-D carbapenemase encountered in different species of Enterobacteriaceae in a Belgian hospital. To study the dispersal of this gene, we describe the comparative analysis of two plasmids containing the blaOXA-427 gene isolated from a Klebsiella pneumoniae and an Enterobacter cloacae complex strain. The two IncA/C2 plasmids containing blaOXA-427 share the same backbone, however, in the K. pneumoniae this plasmid is cointegrated into an IncFIB plasmid forming a 321 kb megaplasmid with multiple multi-resistance regions.

Originele taal-2	English
Artikelnummer	e01448-17
Tijdschrift	Antimicrobial Agents and Chemotherapy
Volume	62
Nummer van het tijdschrift	3
Vroegere onlinedatum	8-jan.-2018
DOI's	https://doi.org/10.1128/AAC.01448-17
Status	Published - mrt.-2018

Toegang tot document

10.1128/AAC.01448-17

Antibiotic Resistance Plasmids Cointegrated into a Megaplasmid HarboringFinal publisher's version, 1,28 MB

Handle.net

Permanente koppeling

Citeer dit

@article{76b3ff21d22448f6b674e3722b896556,

title = "Antibiotic resistance plasmids cointegrated into a megaplasmid harbouring the blaOXA-427 carbapenemase gene",

abstract = "OXA-427 is a new class-D carbapenemase encountered in different species of Enterobacteriaceae in a Belgian hospital. To study the dispersal of this gene, we describe the comparative analysis of two plasmids containing the blaOXA-427 gene isolated from a Klebsiella pneumoniae and an Enterobacter cloacae complex strain. The two IncA/C2 plasmids containing blaOXA-427 share the same backbone, however, in the K. pneumoniae this plasmid is cointegrated into an IncFIB plasmid forming a 321 kb megaplasmid with multiple multi-resistance regions.",

keywords = "Journal Article, SEQUENCE, DISSEMINATION",

author = "Stefanie Desmet and Suruchi Nepal and {van Dijl}, {Jan Maarten} and {Van Ranst}, Marc and Chlebowicz, {Monika A} and Rossen, {John W} and {Van Houdt}, {Jeroen K J} and Piet Maes and Katrien Lagrou and Erik Bathoorn",

note = "Copyright {\textcopyright} 2018 American Society for Microbiology.",

year = "2018",

month = mar,

doi = "10.1128/AAC.01448-17",

language = "English",

volume = "62",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "1098-6596",

publisher = "AMER SOC MICROBIOLOGY",

number = "3",

}

TY - JOUR

T1 - Antibiotic resistance plasmids cointegrated into a megaplasmid harbouring the blaOXA-427 carbapenemase gene

AU - Desmet, Stefanie

AU - Nepal, Suruchi

AU - van Dijl, Jan Maarten

AU - Van Ranst, Marc

AU - Chlebowicz, Monika A

AU - Rossen, John W

AU - Van Houdt, Jeroen K J

AU - Maes, Piet

AU - Lagrou, Katrien

AU - Bathoorn, Erik

PY - 2018/3

Y1 - 2018/3

N2 - OXA-427 is a new class-D carbapenemase encountered in different species of Enterobacteriaceae in a Belgian hospital. To study the dispersal of this gene, we describe the comparative analysis of two plasmids containing the blaOXA-427 gene isolated from a Klebsiella pneumoniae and an Enterobacter cloacae complex strain. The two IncA/C2 plasmids containing blaOXA-427 share the same backbone, however, in the K. pneumoniae this plasmid is cointegrated into an IncFIB plasmid forming a 321 kb megaplasmid with multiple multi-resistance regions.

AB - OXA-427 is a new class-D carbapenemase encountered in different species of Enterobacteriaceae in a Belgian hospital. To study the dispersal of this gene, we describe the comparative analysis of two plasmids containing the blaOXA-427 gene isolated from a Klebsiella pneumoniae and an Enterobacter cloacae complex strain. The two IncA/C2 plasmids containing blaOXA-427 share the same backbone, however, in the K. pneumoniae this plasmid is cointegrated into an IncFIB plasmid forming a 321 kb megaplasmid with multiple multi-resistance regions.

KW - Journal Article

KW - SEQUENCE

KW - DISSEMINATION

U2 - 10.1128/AAC.01448-17

DO - 10.1128/AAC.01448-17

M3 - Article

C2 - 29311088

SN - 1098-6596

VL - 62

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 3

M1 - e01448-17

ER -

Antibiotic resistance plasmids cointegrated into a megaplasmid harbouring the blaOXA-427 carbapenemase gene

Samenvatting

Toegang tot document

Handle.net

Vingerafdruk

Citeer dit