Antigens up the nose: Identification of putative biomarkers for nasal tolerance induction functional studies combined with proteomics

AM Boots, PD Verhaert*, RJT Poele, S Evers, CJ Coenen-de Roo, J Cleven, ES Bos

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

5 Citaten (Scopus)


Intranasal autoantigen delivery is the most effective means of inducing mucosal tolerance and suppression of autoimmune disease. In an effort to identify markers of the "tolerant state", we employed proteomics technology at the level of the cervical lymph node. The analysis revealed that nasal antigen administration (without adiuvant) led to modulation of various proteins among which the most prominent were haptoglobin, nonintegrin 67 kDa laminin receptor, and MRP8. The immunoregulatory haptoglobin may qualify as (bio)marker for effective immunotherapy.

Originele taal-2English
Pagina's (van-tot)1056-1062
Aantal pagina's7
TijdschriftJournal of Proteome Research
Nummer van het tijdschrift5
StatusPublished - 2004

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