Aortic valve prosthesis-patient mismatch and exercise capacity in adult patients with congenital heart disease

Ymkje J. van Slooten, Joost P. Melle, van, Hendrik G. Freling, Berto J. Bouma, Arie P. J. van Dijk, Monique R. M. Jongbloed, Martijn C. Post, Gertjan T. Sieswerda, Anna Huis in 't Veld, Tjark Ebels, Adriaan A. Voors, Petronella G. Pieper*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

10 Citaten (Scopus)


Objectives To report the prevalence of aortic valve prosthesis patient mismatch (PPM) in an adult population with congenital heart disease (CHD) and its impact on exercise capacity. Adults with congenital heart disease (ACHD) with a history of aortic valve replacement may outgrow their prosthesis later in life. However, the prevalence and clinical consequences of aortic PPM in ACHD are presently unknown.

Methods From the national Dutch Congenital Corvitia (CONCUR) registry, we identified 207 ACHD with an aortic valve prosthesis for this cross-sectional cohort study. Severe PPM was defined as an indexed effective orifice area

Results Of the 207 patients, 68% was male, 71% had a mechanical prosthesis and mean age at inclusion was 43.9 years 11.4. The prevalence of PPM was 42%, comprising 23% severe PPM and 19% moderate PPM. Prevalence of PPM was higher in patients with mechanical prostheses (p

Conclusions In this study we report a high prevalence (42%) of PPM in ACHD with an aortic valve prosthesis and an independent association of PPM with diminished exercise capacity.

Originele taal-2English
Pagina's (van-tot)107-113
Aantal pagina's7
Nummer van het tijdschrift2
StatusPublished - jan-2016

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