Samenvatting
Next-generation sequencing (NGS) is a process of massively parallel sequencing of nucleic acids. It can be applied to single pathogens from a pure culture to determine the whole genome but also directly to clinical, animal, and environmental samples to detect microorganisms and antimicrobial resistance markers without a priori knowledge of the target sequences. Genomic identification and characterization of microorganisms in humans and animals are about to become a game-changer for diagnosing, monitoring, and controlling infectious diseases. This thesis aimed to assess the application of culture-dependent and culture-independent NGS approaches in diagnosing and monitoring infectious diseases within and outside the hospital.
Originele taal-2 | English |
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Kwalificatie | Doctor of Philosophy |
Toekennende instantie |
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Begeleider(s)/adviseur |
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Datum van toekenning | 6-apr.-2022 |
Plaats van publicatie | [Groningen] |
Uitgever | |
DOI's | |
Status | Published - 2022 |