Approaches to drug resistance in solid tumors: with emphasis on lung cancer

Marleen Bakker


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De novo or acquired resistance of tumor cells to anticancer agents remains a major problem for the therapeutic efficacy of chemotherapeutic drugs. Most solid tumors are intrinsically insensitive or acquire resistance after initial response to chemotherapy. Different mechanisms seem to play a role in drug resistance such as the overexpression of membrane efflux pumps, a decrease in the activity of target enzymes, and an increase in cellular detoxifying and DNA repair capacity. ... Zie: Summary
Originele taal-2English
KwalificatieDoctor of Philosophy
  • Mulder, H.M., Supervisor, Externe Persoon
  • Ko√ęter, G.H., Supervisor
  • de Vries, Liesbeth, Supervisor
Gedrukte ISBN's9036709210
StatusPublished - 2005

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