Assessing Differences in Articulatory-Acoustic Vowel Space in Parkinson’s Disease by Sex and Phenotype

Nikki Hoekzema, Teja Rebernik*, Thomas Tienkamp, Sasha Chaboksavar, Valentina Ciot, Annetje Gleichman, Roel Jonkers, Aude Noiray, Martijn Wieling, Defne Abur

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review


The goal of this study was to determine whether articulatoryacoustics differ between individuals in the tremor-dominant (TD) and postural instability/gait difficulty (PIGD) phenotypes of Parkinson's disease (PD). The study included 31 individuals with PD (21 TD, 10 PIGD) and 29 control speakers (CS) who were all Dutch native speakers. A read speech task and a semi-spontaneous speech task were completed, and the Articulatory-Acoustic Vowel Space (AAVS) was calculated for both tasks. Results showed no significant difference in AAVS between the overall control group and PD for either phenotype. Follow-up analyses, pooling speech data from our prior study (+27 PD, +23 CS), demonstrated a significantly lower AAVS in males with PD compared to controls and no group differences for females. Thus, articulatory-acoustic changes may be more pronounced for male compared to female speakers with PD, but may not differ by PD phenotype.
Originele taal-2English
TitelProceedings of the 13th International Seminar on Speech Production
StatusPublished - 2024
Evenement13th International Seminar of Speech Production - Autrans, France
Duur: 13-mei-202417-mei-2024


Conference13th International Seminar of Speech Production
Verkorte titelISSP 2024


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