Association between blood pressure levels over time and brain atrophy in the elderly

T den Heijer, [No Value] Skoog, M Oudkerk, FE de Leeuw, JC de Groot, A Hofman, MMB Breteler*

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    91 Citaten (Scopus)

    Samenvatting

    The relation between blood pressure level and degree of global brain atrophy is equivocal. We evaluated past and present blood pressure levels and change in blood pressure over 20 years in relation to the degree of cortical atrophy on magnetic resonance imaging (MRI). In 1995-1996, we measured blood pressure and performed MRI in 1077 nondemented elderly (age 60-90 years). For 513 of these, we had information on a blood pressure level 20 years before. The degree of cortical atrophy was semi-quantitatively scored (range 0-15). In late life, a high (greater than or equal to 90 mmHg) and low (<65 mmHg) diastolic blood pressure were associated with more cortical atrophy than a diastolic blood pressure level between 65-74 mmHg (adjusted difference 0.60 units (95% confidence interval (0), 0.18-1.02) and 0.77 units (0.28-1.25), respectively). Persons whose diastolic blood pressure had declined more than 10 mmHg over 20 years had more cortical atrophy than those with stable blood pressure levels (adjusted difference 0.53 units, 0.05-1.02). Both high and declining diastolic blood pressure levels are associated with more global brain atrophy on MRI. (C) 2002 Elsevier Science Inc. All rights reserved.

    Originele taal-2English
    ArtikelnummerPII S0197-4580(02)00088-X
    Pagina's (van-tot)307-313
    Aantal pagina's7
    TijdschriftNeurobiology of Aging
    Volume24
    Nummer van het tijdschrift2
    StatusPublished - 2003

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