Association of atopic diseases and attention-deficit/hyperactivity disorder: A systematic review and meta-analyses

Jurjen van der Schans*, Rukiye Cicek, Tjalling W. de Vries, Eelko Hak, Pieter J. Hoekstra

*Corresponding author voor dit werk

Onderzoeksoutputpeer review

125 Citaten (Scopus)
250 Downloads (Pure)

Samenvatting

Over the last decades, the hypothesis has been raised that an atopic response could lead to the development of attention-deficit/hyperactivity disorder (ADHD). This study systematically reviews the observational cross-sectional and longitudinal studies that assessed the association between atopic disorders including asthma, atopic eczema, allergic rhinitis, and ADHD in children and adolescents. For longitudinal studies, a weighted Mantel-Haenszel odds ratio of these associations was estimated. The majority of cross-sectional and longitudinal studies reported a statistically significant positive association. The meta-analysis of longitudinal studies revealed an overall weighted odds ratio for asthma of 1.34 (95% confidence interval [CI] 1.24-1.44), 1.32 (95% CI 1.20-1.45) for atopic eczema, and 1.52 (95% CI 1.43-1.63) for allergic rhinitis. Heterogeneity of study data was low (I-2: 0%, p = 0.46 and p = 0.64, respectively) for both studies examining asthma and eczema but substantial for rhinitis studies (I-2: 82%, p = 0.004). This current systematic review provides strong evidence that ADHD is associated with atopic diseases and that individuals have a 30% to 50% greater chance of developing ADHD compared to controls. (C) 2017 Elsevier Ltd. All rights reserved.

Originele taal-2English
Pagina's (van-tot)139-148
Aantal pagina's10
TijdschriftNeuroscience and Biobehavioral Reviews
Volume74
Nummer van het tijdschriftPart A
DOI's
StatusPublished - mrt.-2017

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