Samenvatting
Over the last decades, the hypothesis has been raised that an atopic response could lead to the development of attention-deficit/hyperactivity disorder (ADHD). This study systematically reviews the observational cross-sectional and longitudinal studies that assessed the association between atopic disorders including asthma, atopic eczema, allergic rhinitis, and ADHD in children and adolescents. For longitudinal studies, a weighted Mantel-Haenszel odds ratio of these associations was estimated. The majority of cross-sectional and longitudinal studies reported a statistically significant positive association. The meta-analysis of longitudinal studies revealed an overall weighted odds ratio for asthma of 1.34 (95% confidence interval [CI] 1.24-1.44), 1.32 (95% CI 1.20-1.45) for atopic eczema, and 1.52 (95% CI 1.43-1.63) for allergic rhinitis. Heterogeneity of study data was low (I-2: 0%, p = 0.46 and p = 0.64, respectively) for both studies examining asthma and eczema but substantial for rhinitis studies (I-2: 82%, p = 0.004). This current systematic review provides strong evidence that ADHD is associated with atopic diseases and that individuals have a 30% to 50% greater chance of developing ADHD compared to controls. (C) 2017 Elsevier Ltd. All rights reserved.
Originele taal-2 | English |
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Pagina's (van-tot) | 139-148 |
Aantal pagina's | 10 |
Tijdschrift | Neuroscience and Biobehavioral Reviews |
Volume | 74 |
Nummer van het tijdschrift | Part A |
DOI's | |
Status | Published - mrt.-2017 |