Association of depressive disorders, depression characteristics and antidepressant medication with inflammation

N. Vogelzangs*, H. E. Duivis, A.T.F. Beekman, C. Kluft, J. Neuteboom, W. Hoogendijk, Johannes H. Smit, P. de Jonge, Brenda Penninx

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

202 Citaten (Scopus)
325 Downloads (Pure)

Samenvatting

Growing evidence suggests that immune dysregulation may be involved in depressive disorders, but the exact nature of this association is still unknown and may be restricted to specific subgroups. This study examines the association between depressive disorders, depression characteristics and antidepressant medication with inflammation in a large cohort of controls and depressed persons, taking possible sex differences and important confounding factors into account. Persons (18-65 years) with a current (N = 1132) or remitted (N = 789) depressive disorder according to DSM-IV criteria and healthy controls (N = 494) were selected from the Netherlands Study of Depression and Anxiety. Assessments included clinical characteristics (severity, duration and age of onset), use of antidepressant medication and inflammatory markers (C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha)). After adjustment for sociodemographics, currently depressed men, but not women, had higher levels of CRP (1.33 versus 0.92 mg l(-1), P

Originele taal-2English
Artikelnummere79
Aantal pagina's9
TijdschriftTranslational Psychiatry
Volume2
DOI's
StatusPublished - 21-feb-2012

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