Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials

Willem J A Witlox; Bram L T Ramaekers; Benjamin Lacas; Cecile Le Pechoux; Alexander Sun; Si-Yu Wang; Chen Hu; Mary Redman; Vincent van der Noort; Ning Li; Matthias Guckenberger; Harm van Tinteren; Harry J M Groen; Manuela A Joore; Dirk K M De Ruysscher

doi:10.1016/j.radonc.2021.09.029

Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials

Willem J A Witlox^*, Bram L T Ramaekers, Benjamin Lacas, Cecile Le Pechoux, Alexander Sun, Si-Yu Wang, Chen Hu, Mary Redman, Vincent van der Noort, Ning Li, Matthias Guckenberger, Harm van Tinteren, Harry J M Groen, Manuela A Joore, Dirk K M De Ruysscher

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We assessed the impact of different PCI fractionation schedules (30 Gy in 10 versus 15 fractions) on brain metastases-free survival (BMFS) and toxicity in stage III NSCLC. Our results suggest that 30 Gy in 10 fractions is associated with increased toxicity, while no conclusive evidence of improving BMFS was seen with this schedule.

Originele taal-2	English
Pagina's (van-tot)	163-166
Aantal pagina's	4
Tijdschrift	Radiotherapy and Oncology
Volume	164
DOI's	https://doi.org/10.1016/j.radonc.2021.09.029
Status	Published - nov.-2021

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10.1016/j.radonc.2021.09.029Licentie: CC BY

Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancerFinal publisher's version, 379 KBLicentie: CC BY

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Witlox, W. J. A., Ramaekers, B. L. T., Lacas, B., Pechoux, C. L., Sun, A., Wang, S-Y., Hu, C., Redman, M., van der Noort, V., Li, N., Guckenberger, M., van Tinteren, H., Groen, H. J. M., Joore, M. A., & De Ruysscher, D. K. M. (2021). Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials. Radiotherapy and Oncology, 164, 163-166. https://doi.org/10.1016/j.radonc.2021.09.029

Witlox, Willem J A ; Ramaekers, Bram L T ; Lacas, Benjamin et al. / Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer : A pooled analysis of individual patient data from three randomized trials. In: Radiotherapy and Oncology. 2021 ; Vol. 164. blz. 163-166.

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title = "Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials",

abstract = "We assessed the impact of different PCI fractionation schedules (30 Gy in 10 versus 15 fractions) on brain metastases-free survival (BMFS) and toxicity in stage III NSCLC. Our results suggest that 30 Gy in 10 fractions is associated with increased toxicity, while no conclusive evidence of improving BMFS was seen with this schedule.",

keywords = "Prophylactic cranial irradiation, Non-small cell lung cancer, Brain metastases-free survival, Toxicity, RADIATION-THERAPY, HIGH-RISK, RTOG 0212, CHEMORADIOTHERAPY",

author = "Witlox, {Willem J A} and Ramaekers, {Bram L T} and Benjamin Lacas and Pechoux, {Cecile Le} and Alexander Sun and Si-Yu Wang and Chen Hu and Mary Redman and {van der Noort}, Vincent and Ning Li and Matthias Guckenberger and {van Tinteren}, Harm and Groen, {Harry J M} and Joore, {Manuela A} and {De Ruysscher}, {Dirk K M}",

year = "2021",

month = nov,

doi = "10.1016/j.radonc.2021.09.029",

language = "English",

volume = "164",

pages = "163--166",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "ELSEVIER IRELAND LTD",

}

Witlox, WJA, Ramaekers, BLT, Lacas, B, Pechoux, CL, Sun, A, Wang, S-Y, Hu, C, Redman, M, van der Noort, V, Li, N, Guckenberger, M, van Tinteren, H, Groen, HJM, Joore, MA & De Ruysscher, DKM 2021, 'Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials', Radiotherapy and Oncology, vol. 164, blz. 163-166. https://doi.org/10.1016/j.radonc.2021.09.029

Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer : A pooled analysis of individual patient data from three randomized trials. / Witlox, Willem J A; Ramaekers, Bram L T; Lacas, Benjamin et al.

In: Radiotherapy and Oncology, Vol. 164, 11.2021, blz. 163-166.

Onderzoeksoutput › Academic › peer review

TY - JOUR

T1 - Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer

T2 - A pooled analysis of individual patient data from three randomized trials

AU - Witlox, Willem J A

AU - Ramaekers, Bram L T

AU - Lacas, Benjamin

AU - Pechoux, Cecile Le

AU - Sun, Alexander

AU - Wang, Si-Yu

AU - Hu, Chen

AU - Redman, Mary

AU - van der Noort, Vincent

AU - Li, Ning

AU - Guckenberger, Matthias

AU - van Tinteren, Harm

AU - Groen, Harry J M

AU - Joore, Manuela A

AU - De Ruysscher, Dirk K M

PY - 2021/11

Y1 - 2021/11

N2 - We assessed the impact of different PCI fractionation schedules (30 Gy in 10 versus 15 fractions) on brain metastases-free survival (BMFS) and toxicity in stage III NSCLC. Our results suggest that 30 Gy in 10 fractions is associated with increased toxicity, while no conclusive evidence of improving BMFS was seen with this schedule.

AB - We assessed the impact of different PCI fractionation schedules (30 Gy in 10 versus 15 fractions) on brain metastases-free survival (BMFS) and toxicity in stage III NSCLC. Our results suggest that 30 Gy in 10 fractions is associated with increased toxicity, while no conclusive evidence of improving BMFS was seen with this schedule.

KW - Prophylactic cranial irradiation

KW - Non-small cell lung cancer

KW - Brain metastases-free survival

KW - Toxicity

KW - RADIATION-THERAPY

KW - HIGH-RISK

KW - RTOG 0212

KW - CHEMORADIOTHERAPY

U2 - 10.1016/j.radonc.2021.09.029

DO - 10.1016/j.radonc.2021.09.029

M3 - Article

C2 - 34619235

VL - 164

SP - 163

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JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

SN - 0167-8140

ER -

Witlox WJA, Ramaekers BLT, Lacas B, Pechoux CL, Sun A, Wang S-Y et al. Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials. Radiotherapy and Oncology. 2021 nov.;164:163-166. doi: 10.1016/j.radonc.2021.09.029