Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials

Willem J A Witlox*, Bram L T Ramaekers, Benjamin Lacas, Cecile Le Pechoux, Alexander Sun, Si-Yu Wang, Chen Hu, Mary Redman, Vincent van der Noort, Ning Li, Matthias Guckenberger, Harm van Tinteren, Harry J M Groen, Manuela A Joore, Dirk K M De Ruysscher

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

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We assessed the impact of different PCI fractionation schedules (30 Gy in 10 versus 15 fractions) on brain metastases-free survival (BMFS) and toxicity in stage III NSCLC. Our results suggest that 30 Gy in 10 fractions is associated with increased toxicity, while no conclusive evidence of improving BMFS was seen with this schedule.

Originele taal-2English
Pagina's (van-tot)163-166
Aantal pagina's4
TijdschriftRadiotherapy and Oncology
Volume164
DOI's
StatusPublished - nov.-2021

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