Asymmetric homogeneous hydrogenations at scale

David J. Ager*, Andre H. M. de Vries, Johannes G. de Vries

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

277 Citaten (Scopus)


Asymmetric hydrogenations are increasingly being used to introduce stereogenic centres into products used in the life sciences industries. There are a number of potential pitfalls when moving from a laboratory reaction to a manufacturing process, not least of which is safety. Time-to-market pressure leads to short development times, which in the past could be a large barrier for the implementation of catalytic steps; now there are new ways to minimise this problem. The potential problems associated with impurities and other methods that can shut down the hydrogenation reactions are highlighted in this critical review (353 references).

Originele taal-2English
Pagina's (van-tot)3340-3380
Aantal pagina's41
TijdschriftChemical Society Reviews
Nummer van het tijdschrift8
StatusPublished - 2012
Extern gepubliceerdJa

Citeer dit