@article{05640fdcb094480a85a234fd357caa59,
title = "Asymmetric Synthesis of (S)-2-Indolinecarboxylic Acid by Combining Biocatalysis and Homogeneous Catalysis",
abstract = "(S)-2-Indolinecarboxylic acid, an intermediate for ACE inhibitors, was until recently produced by Fischer indole synthesis and classical resolution in seven steps. However, Perkin condensation to form ortho-chlorocinnamic acid, which is converted to (S)-ortho-chlorophenylalanine using the enzyme phenylalanine ammonia lyase prior to copper-catalyzed ring closure thereof delivers the enantiopure product in just three steps.",
keywords = "homogeneous catalysis, heterocycles, copper, biocatalysis, amino acids",
author = "Lange, {Ben de} and Hyett, {David J.} and Maas, {Peter J.D.} and Daniel Mink and Assema, {Friso B.J. van} and Natascha Sereinig and Vries, {Andr{\'e} H.M. de} and Vries, {Johannes G. de}",
note = "Relation: http://www.rug.nl/fmns-research/stratingh/index date_submitted:2011 Rights: University of Groningen, Stratingh Institute for Chemistry",
year = "2011",
doi = "10.1002/cctc.201000435",
language = "English",
volume = "3",
pages = "289--292",
journal = "ChemCatChem",
publisher = "WILEY-V C H VERLAG GMBH",
number = "2",
}