Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes

Atrial Fibrillation Genetics Conso, Int Stroke Genetics Consortium, Michiel Rienstra, Bastiaan Geelhoed, Yanick P. Hagemeijer, Niek Verweij, Joylene E. Siland, Pim van der Harst

OnderzoeksoutputAcademicpeer review

13 Citaten (Scopus)
169 Downloads (Pure)

Samenvatting

Objective

We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk.

Methods

We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors.

Results

We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p <4.4 x 10(-4) in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 x 10(-48)), explaining similar to 20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07,p = 0.004), but no other primary stroke subtypes (all p > 0.1).

Conclusions

Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.

Originele taal-2English
Artikelnummer293
Aantal pagina's8
TijdschriftNeurology. Genetics
Volume4
Nummer van het tijdschrift6
DOI's
StatusPublished - dec-2018

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