Atrial Fibrillation Genetics Update: Toward Clinical Implementation

Silje Madeleine Kalsto, Joylene Elisabeth Siland, Michiel Rienstra, Ingrid E. Christophersen*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articlepeer review

10 Citaten (Scopus)
103 Downloads (Pure)

Samenvatting

Atrial fibrillation (AF) is the most common heart rhythm disorder worldwide and may have serious cardiovascular health consequences. AF is associated with increased risk of stroke, dementia, heart failure, and death. There are several known robust, clinical risk predictors for AF, such as male sex, increasing age, and hypertension; however, during the last couple of decades, a substantive genetic component has also been established. Over the last 10 years, the discovery of novel AF-related genetic variants has accelerated, increasing our understanding of mechanisms behind AF. Current studies are focusing on mapping the polygenic structure of AF, improving risk prediction, therapeutic development, and patient-specific management. Nevertheless, it is still difficult for clinicians to interpret the role of genetics in AF prediction and management. Here, we provide an overview of relevant topics within the genetics of AF and attempt to provide some guidance on how to interpret genetic advances and their implementation into clinical decision-making.

Originele taal-2English
Artikelnummer127
Aantal pagina's16
TijdschriftFrontiers in cardiovascular medicine
Volume6
DOI's
StatusPublished - 6-sep-2019

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