Attenuation corrected gated SPECT for the assessment of left ventricular ejection fraction and volumes

Riemer H. J. A. Slart*, Rene A. Tio, Clark J. Zeebregts, Antoon T. M. Willemsen, Rudi A. J. O. Dierckx, Johan De Sutter

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

5 Citaten (Scopus)

Samenvatting

Objective The aim of this study was to evaluate the value of attenuation correction (AC) of Tc-99m tetrofosmin single-photon emission tomography (SPECT) imaging for the assessment of left ventricular ejection fraction (LVEF).

Methods Attenuation corrected and non-attenuation corrected (NC) resting Tc-99m tetrofosmin SPECT were compared for the assessment of LVEF. Planar multi-gated radionuclide angiography (MUGA) served as the reference for LVEF assessment. Patients (n = 56) with left ventricular dysfunction who underwent MUGA and rest gated Tc-99m tetrofosmin SPECT within I month were included.

Results The average LVEF on NC gated SPECT was 37.4 +/- 11.8% and on AC SPECT 38.5 +/- 13.4% (P = NS). The absolute mean difference of the LVEF between the MUGA and NC gated SPECT and AC gated SPECT was -0.2% (95% CI -1.7 to 1.3) and -1.3% (95% Cl -2.7 to 0.03), respectively (P = NS both vs. MUGA). The correlation between NC gated SPECT and AC gated SPECT versus MUGA measurement was high with a correlation coefficient of 0.89 (P <0.01) and 0.92 (P <0.01), respectively. End-diastolic volumes (EDVs) and end-systolic volumes (ESVs) were significantly higher with AC gated SPECT when compared with NC gated SPECT (both P <0.001).

Conclusions Profile AC gated Tc-99m tetrofosmin SPECT agrees well with MUGA and NC gated Tc-99m tetrofosmin SPECT for the assessment of LVEF. EDVs and ESVs are significantly higher with AC gated SPECT when compared with NC gated SPECT.

Originele taal-2English
Pagina's (van-tot)171-176
Aantal pagina's6
TijdschriftANNALS OF NUCLEAR MEDICINE
Volume22
Nummer van het tijdschrift3
DOI's
StatusPublished - apr-2008

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