Autophagosome Maturation and Fusion

Fulvio Reggiori, Christian Ungermann

OnderzoeksoutputAcademicpeer review

139 Citaten (Scopus)
779 Downloads (Pure)

Samenvatting

Macroautophagy, or simply autophagy, is a degradative pathway that delivers cytoplasmic components, including cytosol and organelles, to the lysosome in double-membrane vesicles called autophagosomes. This process is initiated at the pre-autophagosomal structure or phagophore assembly site and involves a number of highly conserved autophagy-related proteins. These support the generation and conversion of an open membranous cistern known as the phagophore or isolation membrane into a closed autophagosome. Within this review, we will focus on recent insights into the molecular events following the sealing/completion of an autophagosome, which lead to its maturation and subsequent fusion with endosomes/lysosomes. (C) 2017 The Authors. Published by Elsevier Ltd.

Originele taal-2English
Pagina's (van-tot)486-496
Aantal pagina's11
TijdschriftJournal of Molecular Biology
Volume429
Nummer van het tijdschrift4
DOI's
StatusPublished - 17-feb-2017

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