Autophagy in normal hematopoiesis and leukemia: Biological and therapeutic implications

Hendrik Folkerts

Autophagy in normal hematopoiesis and leukemia: Biological and therapeutic implications

Hendrik Folkerts

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All together the studies in this thesis show that autophagy is an essential survival mechanism for both normal hematopoietic and AML cells and MDS erythroblasts. Altered expression of autophagy-associated genes might have consequences for drug resistance. Therefore, these findings suggest that inhibition of autophagy might be a promising therapeutic strategy for the treatment of AML.

Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Toekennende instantie	Rijksuniversiteit Groningen
Begeleider(s)/adviseur	Vellenga, Edo, Supervisor Schuringa, Jan Jacob, Supervisor Coffer, Paul J., Supervisor, Externe Persoon
Datum van toekenning	25-mrt.-2019
Plaats van publicatie	[Groningen]
Uitgever	Rijksuniversiteit Groningen
Gedrukte ISBN's	978-94-6375-301-2
Status	Published - 2019

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Title and contentsFinal publisher's version, 113 KB
Chapter 1Final publisher's version, 819 KB
Chapter 2Final publisher's version, 7,4 MB
Chapter 3Final publisher's version, 7,05 MB
Chapter 4Final publisher's version, 3,49 MB
Chapter 5Final publisher's version, 7,76 MB
Chapter 6Final publisher's version, 5,77 MB
Chapter 7Final publisher's version, 2,29 MB
Complete thesisFinal publisher's version, 27,3 MB
PropositionsFinal publisher's version, 549 KB

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title = "Autophagy in normal hematopoiesis and leukemia: Biological and therapeutic implications",

abstract = "All together the studies in this thesis show that autophagy is an essential survival mechanism for both normal hematopoietic and AML cells and MDS erythroblasts. Altered expression of autophagy-associated genes might have consequences for drug resistance. Therefore, these findings suggest that inhibition of autophagy might be a promising therapeutic strategy for the treatment of AML.",

author = "Hendrik Folkerts",

year = "2019",

language = "English",

isbn = "978-94-6375-301-2",

publisher = "Rijksuniversiteit Groningen",

school = "University of Groningen",

}

TY - BOOK

T1 - Autophagy in normal hematopoiesis and leukemia

T2 - Biological and therapeutic implications

AU - Folkerts, Hendrik

PY - 2019

Y1 - 2019

N2 - All together the studies in this thesis show that autophagy is an essential survival mechanism for both normal hematopoietic and AML cells and MDS erythroblasts. Altered expression of autophagy-associated genes might have consequences for drug resistance. Therefore, these findings suggest that inhibition of autophagy might be a promising therapeutic strategy for the treatment of AML.

AB - All together the studies in this thesis show that autophagy is an essential survival mechanism for both normal hematopoietic and AML cells and MDS erythroblasts. Altered expression of autophagy-associated genes might have consequences for drug resistance. Therefore, these findings suggest that inhibition of autophagy might be a promising therapeutic strategy for the treatment of AML.

M3 - Thesis fully internal (DIV)

SN - 978-94-6375-301-2

PB - Rijksuniversiteit Groningen

CY - [Groningen]

ER -

Autophagy in normal hematopoiesis and leukemia: Biological and therapeutic implications

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