Autophagy regulation through Atg9 traffic

Sharon A Tooze, Fulvio Reggiori

OnderzoeksoutputAcademicpeer review

42 Citaten (Scopus)
25 Downloads (Pure)

Samenvatting

Rapid membrane expansion is the key to autophagosome formation during nutrient starvation. In this issue, Yamamoto et al. (2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201202061) now provide a mechanism for vesicle-mediated initiation of autophagosome biogenesis. They show that Atg9 vesicles, produced de novo during starvation, are ∼30-60 nm in size and contain ∼30 molecules of Atg9. These vesicles assemble to form an autophagosome, and subsequently, the Atg9 embedded in the outer membrane is recycled to avoid degradation.

Originele taal-2English
Pagina's (van-tot)151-153
Aantal pagina's3
TijdschriftThe Journal of Cell Biology
Volume198
Nummer van het tijdschrift2
DOI's
StatusPublished - 23-jul-2012
Extern gepubliceerdJa

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