Samenvatting
Mito-Biomimetic Lipid Nanocarriers In article number 2305316, Shiqi Wang, Wenguo Cui, Hélder A. Santos, and co-workers show that when cytochrome C and lonidamine co-loaded liposomes enter breast cancer cells, they release the cytochrome C out, which binds with Apaf-1 protein and then assembles into apoptosomes. Since the binding of Cytochrome C and Apaf-1 is prevented by high intracellular ATP levels, the glycolysis inhibitor lonidamine can then reduce ATP and sensitize cytochrome C-induced apoptosome assembly and lead to apoptosis.
Originele taal-2 | English |
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Uitgave | 46 |
DOI's | |
Status | Published - 9-nov.-2023 |