BAIT: Organizing genomes and mapping rearrangements in single cells

Mark Hills*, Kieran O'Neill, Ester Falconer, Ryan Brinkman, Peter M. Lansdorp

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

18 Citaten (Scopus)
230 Downloads (Pure)


Strand-seq is a single-cell sequencing technique to finely map sister chromatid exchanges (SCEs) and other rearrangements. To analyze these data, we introduce BAIT, software which assigns templates and identifies and localizes SCEs. We demonstrate BAIT can refine completed reference assemblies, identifying approximately 21 Mb of incorrectly oriented fragments and placing over half (2.6 Mb) of the orphan fragments in mm10/GRCm38. BAIT also stratifies scaffold-stage assemblies, potentially accelerating the assembling and finishing of reference genomes. BAIT is available at

Originele taal-2English
Aantal pagina's16
TijdschriftGenome medicine
StatusPublished - 13-sep-2013

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