Bcl6 for identification of germinal centres in salivary gland biopsies in primary Sjogren's syndrome

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Histopathological assessment of salivary gland biopsies is an important element of the diagnostic work-up of Sjögren's syndrome (SS) (Fox, 2017; Kroese et al., 2018). Microscopic evaluation of salivary glands of primary SS (pSS) patients reveals characteristic periductal lymphocytic infiltrates (foci), which mainly consist of T- and B-lymphocytes, as well as a variety of non-lymphoid cells, including dendritic cells and macrophages. Over time, these infiltrates may become organised to ectopic lymphoid tissue with T/B cell compartmentalisation, presence of CD21+ follicular dendritic cell (FDC) networks and high endothelial venules (Fisher et al., 2017; Kroese et al., 2014; Kroese et al., 2018; Salomonsson et al., 2003).

Originele taal-2English
Pagina's (van-tot)707-710
Aantal pagina's4
TijdschriftOral diseases
Volume26
Nummer van het tijdschrift3
Vroegere onlinedatum7-jan-2020
DOI's
StatusPublished - 28-jan-2020

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