TY - JOUR
T1 - Bdellovibrio bacteriovorus
T2 - a potential 'living antibiotic' to control bacterial pathogens
AU - Cavallo, Francis M.
AU - Jordana, Lorea
AU - Friedrich, Alexander W.
AU - Glasner, Corinna
AU - van Dijl, Jan Maarten
PY - 2021
Y1 - 2021
N2 - Bdellovibrio bacteriovorus is a small Deltaproteobacterium which, since its discovery, has distinguished itself for the unique ability to prey on other Gram-negative bacteria. The studies on this particular "predatory bacterium", have gained momentum in response to the rising problem of antibiotic resistance, because it could be applied as a potential probiotic and antibiotic agent. Hereby, we present recent advances in the study of B. bacteriovorus, comprehending fundamental aspects of its biology, obligatory intracellular life cycle, predation resistance, and potential applications. Furthermore, we discuss studies that pave the road towards the use of B. bacteriovorus as a "living antibiotic" in human therapy, focussing on its interaction with biofilms, the host immune response, predation susceptibility and in vivo application models. The available data imply that it will be possible to upgrade this predator bacterium from a predominantly academic interest to an instrument that could confront antibiotic resistant infections.
AB - Bdellovibrio bacteriovorus is a small Deltaproteobacterium which, since its discovery, has distinguished itself for the unique ability to prey on other Gram-negative bacteria. The studies on this particular "predatory bacterium", have gained momentum in response to the rising problem of antibiotic resistance, because it could be applied as a potential probiotic and antibiotic agent. Hereby, we present recent advances in the study of B. bacteriovorus, comprehending fundamental aspects of its biology, obligatory intracellular life cycle, predation resistance, and potential applications. Furthermore, we discuss studies that pave the road towards the use of B. bacteriovorus as a "living antibiotic" in human therapy, focussing on its interaction with biofilms, the host immune response, predation susceptibility and in vivo application models. The available data imply that it will be possible to upgrade this predator bacterium from a predominantly academic interest to an instrument that could confront antibiotic resistant infections.
KW - Bdellovibrio bacteriovorus
KW - BALOs
KW - antibiotic resistance
KW - predatory bacteria
KW - “
KW - living antibiotic”
U2 - 10.1080/1040841X.2021.1908956
DO - 10.1080/1040841X.2021.1908956
M3 - Review article
C2 - 33934682
VL - 47
SP - 630
EP - 646
JO - Critical Reviews in Microbiology
JF - Critical Reviews in Microbiology
SN - 0045-6454
ER -