Best Practices to Implement Dried Blood Spot Sampling for Therapeutic Drug Monitoring in Clinical Practice

Marith I Francke*, Laura E J Peeters, D A Hesselink, Sanne M Kloosterboer, Birgit C P Koch, Herman Veenhof, Brenda C M de Winter

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    6 Citaten (Scopus)
    15 Downloads (Pure)


    BACKGROUND: Sampling of blood at home to determine the concentration of drugs or other compounds can be effective in limiting hospital-based sampling. This could lower hospital visits and patient burden, improve the quality of life, and reduce health care costs. Dried blood spot (DBS) microsampling is often used for this purpose, wherein, capillary blood, obtained by pricking the heel or finger, is used to measure different analytes. Although DBS has several advantages over venous blood sampling, it is not routinely implemented in clinical practice. To facilitate the bench to bedside transition, it is important to be aware of certain challenges that need to be considered and addressed.

    RESULTS: Here, important considerations regarding the implementation of DBS in clinical practice, the choice of patients, blood sampling, transport, and laboratory analysis are discussed. In addition, we share our experience and provide suggestions on how to deal with these problems in a clinical setting.

    Originele taal-2English
    Pagina's (van-tot)696-700
    Aantal pagina's5
    TijdschriftTherapeutic Drug Monitoring
    Nummer van het tijdschrift5
    Vroegere onlinedatum23-mei-2022
    StatusPublished - okt.-2022

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