Beyond sepsis: activated protein C and ischemia-reperfusion injury

Marcel Levi, Goda Choi, Ivo Schoots, Marcus Schultz, Tom van der Poll

    OnderzoeksoutputAcademicpeer review

    20 Citaten (Scopus)


    OBJECTIVE: To review potential clinical situations beyond sepsis in which activated protein C might be an effective treatment.

    DATA SOURCE: Published articles between 1970 and 2003 on experimental and clinical studies of activation of both coagulation and inflammation in various disease states.

    DATA SYNTHESIS AND CONCLUSION: The efficacy of activated protein C in sepsis might rely on the fact that it can modulate both coagulation and inflammation. Therefore, administration of activated protein C could be beneficial in disease states that are also characterized by the simultaneous activation of these systems. Ischemia-reperfusion injury of various organs may represent such a state. Indeed, the involvement of the protein C system has been demonstrated in various experimental studies of ischemia-reperfusion, including studies in renal ischemia-reperfusion syndromes, coronary atherosclerosis and acute coronary syndromes, and intestinal ischemia and reperfusion. In some of these models, activated protein C administration, or other interventions in the protein C system, was shown to be beneficial.

    Originele taal-2English
    Pagina's (van-tot)S309-S312
    TijdschriftCritical Care Medicine
    Nummer van het tijdschrift5 Suppl
    StatusPublished - mei-2004

    Citeer dit