@article{884da1fee4e44b38a24df9028b3b78b4,
title = "Biocatalytic Michael-Type Additions of Acetaldehyde to Nitroolefins with the Proline-Based Enzyme 4-Oxalocrotonate Tautomerase Yielding Enantioenriched γ-Nitroaldehydes",
abstract = "Call me Michaelase: The enzyme 4-oxalocrotonate tautomerase (4-OT) promiscuously catalyzes the Michael-type addition of acetaldehyde to a collection of aromatic and aliphatic nitro-olefins with high stereoselectivity producing precursors of g-aminobutyric acid (GABA) analogues (see scheme).",
keywords = "aminobutyric acid, biocatalysis, C-C bond formation, enzymes, Michael-type addition, DIPHENYLPROLINOL SILYL ETHER, PLACEBO-CONTROLLED TRIAL, CARBON BOND FORMATIONS, ALPHA,BETA-UNSATURATED ALDEHYDES, 1,4-ADDITION REACTIONS, BACLOFEN, SUPERFAMILY, PREGABALIN, CATALYSTS, ROLIPRAM",
author = "Geertsema, {Edzard M.} and Yufeng Miao and Tepper, {Pieter G.} and {de Haan}, Pim and Ellen Zandvoort and Poelarends, {Gerrit J.}",
note = "Copyright {\textcopyright} 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2013",
month = oct,
day = "18",
doi = "10.1002/chem.201302351",
language = "English",
volume = "19",
pages = "14407--14410",
journal = "Chemistry",
issn = "1521-3765",
publisher = "Wiley-VCH Verlag GmbH & Co. KGaA",
number = "43",
}