Biocompatible Film‐Coating of Magnetic Soft Robots for Mucoadhesive Locomotion

Chen Wang, Aldona Mzyk, Romana Schirhagl, Sarthak Misra, Venkatsubramanian Kalpathy Venkiteswaran*

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

4 Citaten (Scopus)
34 Downloads (Pure)

Samenvatting

Magnetically-actuated soft robots for medical applications are required to be functional, biocompatible, as well as capable of robust motion inside human organs. In this paper, a ring-shaped magnetic soft robot, with a flexible biopolymeric film coating, capable of motion on mucus-coated surfaces is designed and investigated. The biopolymeric film made from chitosan–glycerol (C–G) solution endows the robot with robust locomotion capabilities on surfaces of diverse geometrical shapes and orientations. By utilizing mucoadhesive locomotion, the robot has the potential to carry out clinical procedures on enclosed mucus-coated tissue surfaces. Material characterization shows that the mucoadhesion increases with the increase of contact times and/or preload forces. The softness of the C–G film can be adjusted by controlling the concentration of glycerol. The ring-shaped design and magnetization profile decouple the locomotion and functions of the robot. Additionally, the C–G film-coated robot is tested to be biocompatible for a human colorectal adenocarcinoma cell line with epithelial morphology (HT29). The C–G film reduces the negative effects (superoxide generation) of ferromagnetic particles. Three robot functions including pick-and-place, cargo transportation, and liquid capsule release are demonstrated on different surfaces to show the maneuverability, functionality, and potential of implementing clinical procedures through mucoadhesion.

Originele taal-2English
Artikelnummer2201813
Aantal pagina's13
TijdschriftAdvanced Materials Technologies
Volume8
Nummer van het tijdschrift12
Vroegere onlinedatum16-mrt.-2023
DOI's
StatusPublished - 23-jun.-2023

Vingerafdruk

Duik in de onderzoeksthema's van 'Biocompatible Film‐Coating of Magnetic Soft Robots for Mucoadhesive Locomotion'. Samen vormen ze een unieke vingerafdruk.

Citeer dit