Background: We evaluate pregnancy outcome and anticoagulation regimes in women with mechanical and biological prosthetic heart valves (PHV) for congenital heart disease.
Methods: Retrospective multicenter cohort studying pregnancy outcomes in an existing cohort of patients with PHV.
Results: 52 women had 102 pregnancies of which 78 pregnancies (46 women) >= 20 weeks duration (59 biological, 19 mechanical PHV). Miscarriages (n = 19,
Conclusion: Complications occur more often in pregnancies of women with a mechanical PHV than in women with a biological PHV, mainly caused by PHV thrombosis and bleeding complications. Meticulous monitoring of anticoagulation in pregnant women is necessary. Women with a pulmonary mechanical PHV are at high risk of complications. (C) 2018 Published by Elsevier B.V.