@article{1f8223afe5f440059e3419bb9ee7dce8,
title = "Biomarker profiling of steroid-resistant acute GVHD in patients after infusion of mesenchymal stromal cells",
abstract = "We performed a prospective phase II study to evaluate clinical safety and outcome in 48 patients with steroid-refractory grade II-IV acute graft-versus-host disease (aGVHD) treated with mesenchymal stromal cells (MSCs). Clinical outcomes were correlated to comprehensive analyses of soluble and cellular biomarkers. Complete resolution (CR) of aGVHD at day 28 (CR-28) occurred in 12 (25%) patients, CR lasting 41 month (CR-B) occurred in 24 (50%) patients. One-year overall survival was significantly improved in CR-28 (75 versus 33%, P = 0.020) and CR-B (79 versus 8%, P",
keywords = "VERSUS-HOST-DISEASE, CLINICAL-TRIALS NETWORK, STEM-CELLS, DENDRITIC CELLS, REFRACTORY ACUTE, IN-VIVO, LYMPHOCYTE-PROLIFERATION, PEDIATRIC-PATIENTS, PHASE I/II, THERAPY",
author = "{te Boome}, {L. C. J.} and C. Mansilla and {van der Wagen}, {L. E.} and Lindemans, {C. A.} and Petersen, {E. J.} and E. Spierings and Thus, {K. A.} and K. Westinga and M. Plantinga and M. Bierings and Broers, {A. E. C.} and Cuijpers, {M. L. H.} and {van Imhoff}, {G. W.} and Janssen, {J. J.} and C. Huisman and S. Zeerleder and G. Huls and Boelens, {J. J.} and Wulffraat, {N. M.} and Slaper-Cortenbach, {I. C. M.} and J. Kuball",
year = "2015",
month = sep,
doi = "10.1038/leu.2015.89",
language = "English",
volume = "29",
pages = "1839--1846",
journal = "Leukemia",
issn = "0887-6924",
publisher = "Nature Publishing Group",
number = "9",
}