Biomarkers and personalized medicine in heart failure


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    Treating heart failure is one of the greatest unmet needs in cardiovascular medicine today. Overall survival is poor and 50% of patients die within 5 years of their initial diagnosis. Heart failure is a heterogeneous syndrome and a one-size-fits-all approach is ineffective. Therefore, in my thesis I used biomarkers to 1. Show that patients with heart failure and a preserved ejection fraction are subject to more inflammation, which can be a key treatment target and 2. Identified clinical relevant subgroups with differences in response to treatment using machine learning based approaches.
    Originele taal-2English
    KwalificatieDoctor of Philosophy
    Toekennende instantie
    • Rijksuniversiteit Groningen
    • van der Meer, Peter, Supervisor
    • Voors, Adriaan, Supervisor
    • Brunner-La Rocca, Hans-Peter, Beoordelingscommissie, Externe Persoon
    • van Gilst, Wiek, Beoordelingscommissie
    Datum van toekenning17-sep.-2018
    Plaats van publicatie[Groningen]
    Gedrukte ISBN's978-94-034-1064-7
    Elektronische ISBN's978-94-034-1063-0
    StatusPublished - 2018


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