Biomaterials in search of a meniscus substitute

Jan J. Rongen*, Tony G. van Tienen, Bas van Bochove, Dirk. W. Grijpma, Pieter Buma

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

63 Citaten (Scopus)

Samenvatting

The menisci fulfill key biomechanical functions in the tibiofemoral (knee) joint. Unfortunately meniscal injuries are quite common and most often treated by (partial) meniscectomy. However, some patients experience enduring symptoms, and, more importantly, it leads to an increased risk for symptomatic osteoarthritis. Over the past decades, researchers have put effort in developing a meniscal substitute able to prevent osteoarthritis and treat enduring clinical symptoms. Grossly, two categories of substitutes are observed: First, a resorbable scaffold mimicking biomechanical function which slowly degrades while tissue regeneration and organization is promoted. Second, a non resorbable, permanent implant which mimics the biomechanical function of the native meniscus. Numerous biomaterials with different (material) properties have been used in order to provide such a substitute. Nevertheless, a clinically applicable cartilage protecting material is not yet emerged. In the current review we provide an overview, and discuss, these different materials and extract recommendations regarding material properties for future developmental research. (C) 2014 Elsevier Ltd. All rights reserved.

Originele taal-2English
Pagina's (van-tot)3527-3540
Aantal pagina's14
TijdschriftBiomaterials
Volume35
Nummer van het tijdschrift11
DOI's
StatusPublished - apr-2014

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