Biomedical Applications of Nanodiamonds in Microbiology

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    The studies in this dissertation represent stepping stones toward the potential applications of nanodiamonds in a microbiological environment. The usefulness of Fluorescent Nanodiamonds(FNDs) as sensors for detecting free radical species in bacteria and Detonation Nanodiamonds(DNDs) potential as antibactericidal coating have been considered in this thesis. FNDs reveal no antibacterial effect in the concentration range relevant for biosensing applications. Reduction of colony formation of S. aureus due to interaction with nanodiamonds does not result from toxicity, but aggregation. Nanodiamonds can be introduced as a tool to measure free radicals in live organisms and microorganisms including bacteria. T1 measurements reveal the magnetic noise of free radical existence surrounding the NV- center. Relaxometry allows us to measure the dynamic of free radical generation in real-time. Relaxometry has proven its advantages but there is room for improvement. Mechanically or chemically engineering of surface properties of black silicon or black Diamond is a promising approach to directly repel bacteria.
    Originele taal-2English
    KwalificatieDoctor of Philosophy
    Toekennende instantie
    • Rijksuniversiteit Groningen
    Begeleider(s)/adviseur
    • Schirhagl, Romana, Supervisor
    • Najafi, Mohammad B. Habibi, Supervisor, Externe Persoon
    Datum van toekenning23-nov.-2022
    Plaats van publicatie[Groningen]
    Uitgever
    DOI's
    StatusPublished - 2022

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