Biophysical Interactions of vaginal microorganisms

Jessica Anne Younes

Biophysical Interactions of vaginal microorganisms

Vertaalde titel van de bijdrage: Biofysische Interacties van vaginale microorganismen

Jessica Anne Younes

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Vaginale gezondheid is altijd al belangrijk geweest. Echter, pas sinds kort wordt het steeds duidelijker hoe de vaginale gezondheid het beste gehandhaafd kan worden. Helaas zijn vaginale infecties een vaak voorkomend probleem, dat moeilijk te behandelen is en waarover bovendien nog maar weinig bekend is. Infecties worden vaak veroorzaakt door veranderingen in de samenstelling van de vaginale microbiota en kunnen leiden tot ernstige gezondheidsproblemen voor de vrouw en/of haar ongeboren kind. Normale vaginale microbiota (meestal Lactobacillus sp.) en probiotische bacteriën bieden hier veelbelovende kansen voor preventie en therapie. De focus van dit proefschrift ligt op het belang van de adhesie tussen de vaginale bacteriën (pathogenen en lactobacilli) en tussen bacteriën en vaginale cellen, waarbij gekeken wordt hoe dit de condities in een vaginale infectie kan beïnvloeden (b.v. inflammatie, biofilm formatie, productie van toxines etc.). Adhesieve lactobacillen (lactobacillen die aan elkaar of aan de celwand vastkleven) zijn beter in staat om pathogene virulentie, inflammatie en biofilm formatie te voorkomen dan niet-adhesieve lactobacillen. Pathogenen blijken beter aan vaginale cellen vast te kleven, terwijl lactobacillen beter aan de pathogenen zelf vastkleven. Dit laatste verschijnsel is mogelijk het mechanisme dat de gunstige werking van lactobacillen verklaart. Samenvattend kunnen we concluderen dat adhesie door de vaginale bacteriën een belangrijke factor is die nog beter onderzocht moet worden.

Vertaalde titel van de bijdrage	Biofysische Interacties van vaginale microorganismen
Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Toekennende instantie	Rijksuniversiteit Groningen
Begeleider(s)/adviseur	van der Mei, Henny, Supervisor Busscher, Henk, Supervisor Reid, G, Supervisor, Externe Persoon
Datum van toekenning	6-mei-2015
Plaats van publicatie	[Groningen]
Uitgever	University of Groningen
Gedrukte ISBN's	978-90-367-7842-8
Elektronische ISBN's	978-90-367-7841-1
Status	Published - 2015

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Title and contentsFinal publisher's version, 241 KB
Chapter 1Final publisher's version, 690 KB
Chapter 2Final publisher's version, 492 KB
Chapter 3Final publisher's version, 529 KB
Chapter 4Final publisher's version, 842 KB
Chapter 5Final publisher's version, 826 KB
Chapter 6Final publisher's version, 230 KB
AppendicesFinal publisher's version, 231 KB
Complete dissertationFinal publisher's version, 2,87 MB
PropositionsFinal publisher's version, 40,2 KB

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title = "Biophysical Interactions of vaginal microorganisms",

abstract = "Vaginal health has always been important, but current research is just starting to be able to explain why and how to maintain it. Unfortunately, vaginal infections are very common, hard to treat, and poorly understood. Infections caused by changes in the vaginal bacterial community can lead to serious health consequences for a woman and any children she may bear. Normal vaginal bacteria (generally Lactobacillus sp.) and probiotic bacteria show promising directions for prevention and therapy. This thesis looks at the importance of adhesion between vaginal bacteria (pathogens and lactobacilli) and between bacteria and vaginal cells to see how it affects circumstances commonly seen in vaginal infection (e.g. inflammation, biofilm formation, toxin production, etc). Adhesive lactobacilli bacteria are better able to reduce pathogen virulence, inflammation, and biofilm formation than non-adhesive ones. Pathogenic bacteria seem to stick more strongly to vaginal cells, but lactobacilli adhere better to the pathogens themselves, and perhaps this is one of the mechanisms by which they exert their beneficial influence. Adhesion is an important factor that should be further investigated among vaginal bacteria.",

author = "Younes, {Jessica Anne}",

year = "2015",

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T1 - Biophysical Interactions of vaginal microorganisms

AU - Younes, Jessica Anne

PY - 2015

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N2 - Vaginal health has always been important, but current research is just starting to be able to explain why and how to maintain it. Unfortunately, vaginal infections are very common, hard to treat, and poorly understood. Infections caused by changes in the vaginal bacterial community can lead to serious health consequences for a woman and any children she may bear. Normal vaginal bacteria (generally Lactobacillus sp.) and probiotic bacteria show promising directions for prevention and therapy. This thesis looks at the importance of adhesion between vaginal bacteria (pathogens and lactobacilli) and between bacteria and vaginal cells to see how it affects circumstances commonly seen in vaginal infection (e.g. inflammation, biofilm formation, toxin production, etc). Adhesive lactobacilli bacteria are better able to reduce pathogen virulence, inflammation, and biofilm formation than non-adhesive ones. Pathogenic bacteria seem to stick more strongly to vaginal cells, but lactobacilli adhere better to the pathogens themselves, and perhaps this is one of the mechanisms by which they exert their beneficial influence. Adhesion is an important factor that should be further investigated among vaginal bacteria.

AB - Vaginal health has always been important, but current research is just starting to be able to explain why and how to maintain it. Unfortunately, vaginal infections are very common, hard to treat, and poorly understood. Infections caused by changes in the vaginal bacterial community can lead to serious health consequences for a woman and any children she may bear. Normal vaginal bacteria (generally Lactobacillus sp.) and probiotic bacteria show promising directions for prevention and therapy. This thesis looks at the importance of adhesion between vaginal bacteria (pathogens and lactobacilli) and between bacteria and vaginal cells to see how it affects circumstances commonly seen in vaginal infection (e.g. inflammation, biofilm formation, toxin production, etc). Adhesive lactobacilli bacteria are better able to reduce pathogen virulence, inflammation, and biofilm formation than non-adhesive ones. Pathogenic bacteria seem to stick more strongly to vaginal cells, but lactobacilli adhere better to the pathogens themselves, and perhaps this is one of the mechanisms by which they exert their beneficial influence. Adhesion is an important factor that should be further investigated among vaginal bacteria.

M3 - Thesis fully internal (DIV)

SN - 978-90-367-7842-8

PB - University of Groningen

CY - [Groningen]

ER -

Biophysical Interactions of vaginal microorganisms

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